HCG (Human Chorionic Gonadotropin) Reference Guide

Field Value
Name Human Menopausal Gonadotropin (HMG)
Reference Code HMG
Category Sexual Health / Fertility Gonadotropin
Example Strength 75 IU vial
Reference Range 75–150 IU per injection
Frequency 3 times weekly
Key Safety Warning Risk of ovarian hyperstimulation syndrome (OHSS) in women. Multiple pregnancy risk. Requires specialist supervision.

Mechanism of Action (Educational)

HMG is a purified urinary-derived gonadotropin preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.

In women, HMG stimulates ovarian follicular development. In men, it promotes spermatogenesis by stimulating Sertoli cell function.

It is often used in combination or sequentially with HCG in fertility protocols.

Indications (Regulatory / Off-Label)

  • FDA-approved: Female infertility
  • FDA-approved: Hypogonadotropic hypogonadism
  • Off-label: Male fertility preservation during TRT

Administration (Clinical Use)

Parameter Details
Route Intramuscular or Subcutaneous
Frequency 3 times weekly
Injection Sites IM: gluteal
SQ: abdomen
Timing Maintain consistent weekly schedule

Titration Schedule (Clinical Framework)

  • Weeks 1–4: 75 IU, 3x weekly
  • Weeks 5+: 75–150 IU, 3x weekly based on response

Dose adjustments should be made under specialist supervision.

Pharmacokinetics (Literature)

  • Half-life: ~20–40 hours
  • Spermatogenesis effects require months of therapy

Reconstitution & Concentration
(Mathematical Illustration Only)

Parameter Value
Diluent Provided sterile diluent
Reconstitution Volume 1 mL
Resulting Concentration 75 IU/mL
Stability Use within 7 days refrigerated

Reconstitution Math Example

  • 75 IU ÷ 1 mL = 75 IU/mL
  • 0.5 mL = 37.5 IU
  • 1 mL = 75 IU

Provided strictly for arithmetic reference only.

Mathematical Calculation Tool

The calculator below allows concentration and volume calculations based on vial strength and dilution volume. This tool is provided strictly for mathematical reference.

Peptide Reconstitution Calculator

For Educational & Professional Reference Only

⚠️ This is a mathematical reference tool only. No medical or dosing advice is provided.

Safety & Contraindications (Summary)

Contraindications

  • Primary ovarian failure
  • Primary testicular failure
  • Hormone-sensitive tumors
  • Pregnancy

Drug Interactions

  • HCG (synergistic; commonly used sequentially)

Adverse Events

  • Injection site reactions
  • Abdominal bloating
  • Headache

Serious Risks

  • Ovarian hyperstimulation syndrome (OHSS)
  • Multiple pregnancy

Monitoring (Clinical Framework)

  • FSH / LH levels
  • Estradiol (women)
  • Testosterone (men)
  • Semen analysis

Disclaimer

HMG is FDA-approved for infertility indications. Use requires specialist supervision. This content is provided strictly for educational and professional reference purposes. All clinical decisions must be made by a licensed healthcare professional.

Reference Sources